Forgetfulness and it's Causes

	Forgetfulness: It's Not Always What You Think

Introduction

Many older people worry about becoming more forgetful. They think forgetfulness is the first sign of Alzheimer's disease. In the past, memory loss and confusion were considered a normal part of aging. However, scientists now know that most people remain both alert and able as they age, although it may take them longer to remember things.

A lot of people experience memory lapses. Some memory problems are serious, and others are not. People who have serious changes in their memory, personality, and behavior may suffer from a form of brain disease called dementia. Dementia seriously affects a person's ability to carry out daily activities. Alzheimer's disease is one of many types of dementia.

The term dementia describes a group of symptoms that are caused by changes in brain function. Dementia symptoms may include asking the same questions repeatedly; becoming lost in familiar places; being unable to follow directions; getting disoriented about time, people, and places; and neglecting personal safety, hygiene, and nutrition. People with dementia lose their abilities at different rates.

Dementia is caused by many conditions. Some conditions that cause dementia can be reversed, and others cannot. Further, many different medical conditions may cause symptoms that seem like Alzheimer's disease, but are not. Some of these medical conditions may be treatable. Reversible conditions can be caused by a high fever, dehydration, vitamin deficiency and poor nutrition, bad reactions to medicines, problems with the thyroid gland, or a minor head injury. Medical conditions like these can be serious and should be treated by a doctor as soon as possible.

Sometimes older people have emotional problems that can be mistaken for dementia. Feeling sad, lonely, worried, or bored may be more common for older people facing retirement or coping with the death of a spouse, relative, or friend. Adapting to these changes leaves some people feeling confused or forgetful. Emotional problems can be eased by supportive friends and family, or by professional help from a doctor or counselor.

The two most common forms of dementia in older people are Alzheimer's disease and multi-infarct dementia (sometimes called vascular dementia). These types of dementia are irreversible, which means they cannot be cured. In Alzheimer's disease, nerve cell changes in certain parts of the brain result in the death of a large number of cells. Symptoms of Alzheimer's disease begin slowly and become steadily worse. As the disease progresses, symptoms range from mild forgetfulness to serious impairments in thinking, judgment, and the ability to perform daily activities. Eventually, patients may need total care.

In multi-infarct dementia, a series of small strokes or changes in the brain's blood supply may result in the death of brain tissue. The location in the brain where the small strokes occur determines the seriousness of the problem and the symptoms that arise. Symptoms that begin suddenly may be a sign of this kind of dementia. People with multi-infarct dementia are likely to show signs of improvement or remain stable for long periods of time, then quickly develop new symptoms if more strokes occur. In many people with multi-infarct dementia, high blood pressure is to blame. One of the most important reasons for controlling high blood pressure is to prevent strokes.

Diagnosis

People who are worried about memory problems should see their doctor. If the doctor believes that the problem is serious, then a thorough physical, neurological, and psychiatric evaluation may be recommended. A complete medical examination for memory loss may include gathering information about the person's medical history, including use of prescription and over-the-counter medicines, diet, past medical problems, and general health. Because a correct diagnosis depends on recalling these details accurately, the doctor also may ask a family member for information about the person.

Tests of blood and urine may be done to help the doctor find any problems. There are also tests of mental abilities (tests of memory, problem solving, counting, and language). A brain CT scan may assist the doctor in ruling out a curable disorder. A scan also may show signs of normal age-related changes in the brain. It may be necessary to have another scan at a later date to see if there have been further changes in the brain.

Alzheimer's disease and multi-infarct dementia can exist together, making it hard for the doctor to diagnose either one specifically. Scientists once thought that multi-infarct dementia and other types of vascular dementia caused most cases of irreversible mental impairment. They now believe that most older people with irreversible dementia have Alzheimer's disease.

Treatment

Even if the doctor diagnoses an irreversible form of dementia, much still can be done to treat the patient and help the family cope. A person with dementia should be under a doctor's care, and may see a neurologist, psychiatrist, family doctor, internist, or geriatrician. The doctor can treat the patient's physical and behavioral problems and answer the many questions that the person or family may have.

For some people in the early and middle stages of Alzheimer's disease, the drug tacrine (also known as Cognex or THA) is prescribed to possibly delay the worsening of some of the disease's symptoms. Doctors believe it is very important for people with multi-infarct dementia to try to prevent further strokes by controlling high blood pressure, monitoring and treating high blood cholesterol and diabetes, and not smoking.

Many people with dementia need no medication for behavioral problems. But for some people, doctors may prescribe medications to reduce agitation, anxiety, depression, or sleeping problems. These troublesome behaviors are common in people with dementia. Careful use of doctor-prescribed drugs may make some people with dementia more comfortable and make caring for them easier.

A healthy diet is important. Although no special diets or nutritional supplements have been found to prevent or reverse Alzheimer's disease or multi-infarct dementia, a balanced diet helps maintain overall good health. In cases of multi-infarct dementia, improving the diet may play a role in preventing more strokes.

Family members and friends can assist people with dementia in continuing their daily routines, physical activities, and social contacts. People with dementia should be kept up to date about the details of their lives, such as the time of day, where they live, and what is happening at home or in the world. Memory aids may help in the day-to-day living of patients in the earlier stages of dementia. Some families find that a big calendar, a list of daily plans, notes about simple safety measures, and written directions describing how to use common household items are very useful aids.

Alternative Treatments for Alzheimer's and Dementia

Supplements

Vitamin E: Alzheimer's is caused to some extent by oxidative damage to brain tissue. Antioxidant nutrients may help prevent and repair this damage. In a study by Columbia University researchers, vitamin E (2,000 IU/day) slowed the cognitive deterioration in people with Alzheimer's about as much as the prescription drugs used to treat the disease.

Acetyl-L-Carnitine: this natural substance, often called carnitine, increases levels of acetylcholine, the neurotransmitter that gets depleted in Alzheimer's. Several studies show that Acetyl-L-Carnitine slows the cognitive deterioration of Alzheimer's. Subjects in these studies took 1,000 mg twice a day.

Herbs

Ginkgo Biloba: many studies show that ginkgo improves blood flow throughout the body, especially the brain. Several studies show that the herb helps improve the cognitive functioning of non-demented elderly people with poor brain blood flow (cerebral insufficiency). A study by researchers at Albert Einstein College of Medicine in New York City showed that ginkgo extract (120 mg/day) slows the progression of Alzheimer's disease about as much as the prescription drugs used to treat the disease.

A wide variety of supplements have also been shown to help with cognitive health and overall brain fitness.

Advice for Today

Scientists are working to develop new drugs that someday may slow, reverse, or prevent the damage caused by Alzheimer's disease and multi- infarct dementia. In the meantime, people who have no dementia symptoms can try to keep their memory sharp.

Some suggestions include developing interests or hobbies and staying involved in activities that stimulate both the mind and body. Giving careful attention to physical fitness and exercise also may go a long way toward keeping a healthy state of mind. Limiting the use of alcoholic beverages is important, because heavy drinking over time can cause permanent brain damage.

Many people find it useful to plan tasks; make "things-to-do" lists; and use notes, calendars, and other memory aids. They also may remember things better by mentally connecting them to other meaningful things, such as a familiar name, song, or lines from a poem.

Stress, anxiety, or depression can make a person more forgetful. Forgetfulness caused by these emotions usually is temporary and goes away when the feelings fade. However, if these feelings last for a long period of time, getting help from a professional is important. Treatment may include counseling or medication, or a combination of both.

Some physical and mental changes occur with age in healthy people. However, much pain and suffering can be avoided if older people, their families, and their doctors recognize dementia as a disease, not part of normal aging.

Preventing Alzheimer's

There is no known way of avoiding or preventing Alzheimer's disease. Studies have shown that much can be done to slow the progression of the disease.

Secondary Prevention

Family members who want to learn about their possible predisposition to Alzheimer's should consult their doctors about genetic screening for the presence of the E4 allele of apolipoprotein E gene and other genetic traits. Those who carry the allele may be at a greater risk to become afflicted with Alzheimer's.

Resources

Having accurate, current information about dementia also is important. The Alzheimer's Disease Education and Referral (ADEAR) Center is a clearinghouse supported by the National Institute on Aging. For more information about Alzheimer's disease and multi-infarct dementia, contact:

ADEAR Center
PO Box 8250
Silver Spring, MD 20907-8250
toll-free 800-438-4380
e-mail: adear@alzheimers.org
Internet Web site: http://www.alzheimers.org/adear/

Alzheimer's Association
919 N. Michigan Ave. Suite 1000
Chicago, IL 60611-1676
Phone: (800) 272-3900
or (312) 335-8700
www.alz.org

Alzheimer's Association of St. Louis
9374 Olive Boulevard
St. Louis, Missouri 63132-3214
Phone: (314) 432-3422
or (800) 980-9080
Fax: (314) 432-3824
E-Mail: info@alzstl.org
www.alzstl.org

Alzheimer & Dementia Summit Medical Center
Phone: (510) 869-8911
Email: info@summitmed.com
www.summitmed.com/alzheim.htm

Bruce Reed, Ph.D. Alzheimer's Disease Center
150 Muir Road (127A)
Martinez, CA 94553-4612
Phone: (925) 372-2485

California Department of Aging
1600 K Street
Sacramento, California 95814
Phone: (916) 322-5290

Health Net
www.alzheimers.com

Information About Alzheimer's Disease

MEDITOPIA
www.meditopia.com/alzhome.html

San Francisco Alzheimer's and Dementia Clinic
909 Hyde Street, Suite 230
San Francisco, California 94109
Phone: (415) 673-4600
Fax: (415) 673-9532
E-mail: SFHACLIN@aol.com
www.citilinks.com/sfadc/

Families often need information about community resources, such as home care, adult day care, respite programs, and nursing homes. This information usually is available from State and Area Agencies on Aging. For help in finding the appropriate agency in your area, call the Eldercare Locator, toll-free at 800-677-1116.

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